ALERT

In Observance of U.S. holiday, Memorial Day, Agilent Cross Lab/ iLab Operations Software will be closed during U.S. hours on Monday May 28th, 2018. EU and APAC support coverage will remain open during this time. We will resume U.S. support hours on Tuesday May 29th, 2018. For urgent matters, please add "Urgent" to the ticket subject and we will prioritize those requests first.

Translational Laboratory Shared Service (UMGCC)

Overview of Services

The University of Maryland Marlene and Stewart Greenebaum Cancer Center (UMGCC) Translational Shared Service (TLSS) offers pre-clinical and clinical experimental support to basic researchers and physicians in the UMGCC community. We work in areas across the entire spectrum: cell biology, in vitro, in vivo and human trials. 

 

In Vitro Assays 

  • IC50 generation
  • Cell cycle (propidium iodide)
  • Viability (trypan blue exclusion)
  • Apoptosis
  • DNA Damage (Gamma-H2Ax Immunofluorescence)
  • Potentiation/Synergy
  • ROS
  • Western Analysis
  • Telomere Length Assay (QPCR)
  • Angiogenesis
  • Mycoplasma testing

 

Xcelligence 

  • Real time proliferation/invasion/migration

 

In Vivo Assays 

  • IACUC approved umbrella protocol
  • Tolerability:
  • Tumor Growth
  • Pharmacokinetics: generation of plasma
  • Efficacy (flank models)
  • Efficacy (orthotopic models)
  • Pharmacodynamic Endpoints
  • Imaging of cells with Xenogen System
  • Necropsy

 

Clinical Trial Support 

We isolate:

  • Plasma
  • Serum
  • Tumor Biopsy
  • Whole Blood (isolation of PBMC,
  • DNA, RNA, protein)
  • Bone Marrow (isolation of marrow
    cells)
  • Buccal Mucosa

 

Pharmacodynamic (PD) Endpoints 

  • in patient samples, tumor or surrogate tissues, preclinical samples
  • endpoint dependent on target (e.g., ELISA, flow cytometry, Western, unique assay)

Pleas acknowledge our core in your publications when appropriate in the format that follows:  “University of Maryland School of Medicine Center for Innovative Biomedical Resources, Translation Laboratory Shared Services Core – Baltimore, Maryland.

Leadership

Rena Lapidus, Ph.D., Director

Location and Hours of Operation

Hours Location

Monday - Friday    

8:30 am - 5:00 pm       

655 West Baltimore Street

Baltimore, MD  21201

Links and Resources

University of Maryland School of Medicine - Translational Core Laboratory

Biotek Synergy H1 Multimode Plate Reader

xCELLigence RTCA DP

 

Contacts

Name Role Phone Email Location
Rena Lapidus, PhD
Core Director
 
410-328-8092
 
RLapidus@som.umaryland.edu
 
9-037 BRB
 
Brandon Carter-Cooper
Lab Manager
 
410-706-2171
 
BCooper@som.umaryland.edu
 
7-010C BRB
 
Eun Yong Choi
In Vivo Manager
 
410-706-2171
 
echoi@som.umaryland.edu
 
7-010C BRB
 
Elizabeth Chang
Post-Doctoral Fellow
 
410-706-2171
 
echang@som.umaryland.edu
 
7-010C BRB
 
Julian Kang
Research Assistant
 
410-706-2171
 
jkang@som.umaryland.edu
 
7-010C BRB
 

Service list


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Clinical (5)
In Vitro (26)
In Vivo (17)
Plate Reader Fees (1)
xCELLigence Run Fees (3)


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