Translational Laboratory Shared Service (UMGCC)

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Overview of Services

The University of Maryland Marlene and Stewart Greenebaum Cancer Center (UMGCC) Translational Shared Service (TLSS) offers pre-clinical and clinical experimental support to basic researchers and physicians in the UMGCC community. We work in areas across the entire spectrum: cell biology, in vitro, in vivo and human trials. 

 

In Vitro Assays 

  • IC50 generation
  • Cell cycle (propidium iodide)
  • Viability (trypan blue exclusion)
  • Apoptosis
  • DNA Damage (Gamma-H2Ax Immunofluorescence)
  • Potentiation/Synergy
  • ROS
  • Western Analysis
  • Telomere Length Assay (QPCR)
  • Angiogenesis
  • Mycoplasma testing

 

Xcelligence 

  • Real time proliferation/invasion/migration

 

In Vivo Assays 

  • IACUC approved umbrella protocol
  • Tolerability:
  • Tumor Growth
  • Pharmacokinetics: generation of plasma
  • Efficacy (flank models)
  • Efficacy (orthotopic models)
  • Pharmacodynamic Endpoints
  • Imaging of cells with Xenogen System
  • Necropsy

 

Clinical Trial Support 

We isolate:

  • Plasma
  • Serum
  • Tumor Biopsy
  • Whole Blood (isolation of PBMC,
  • DNA, RNA, protein)
  • Bone Marrow (isolation of marrow
    cells)
  • Buccal Mucosa

 

Pharmacodynamic (PD) Endpoints 

  • in patient samples, tumor or surrogate tissues, preclinical samples
  • endpoint dependent on target (e.g., ELISA, flow cytometry, Western, unique assay)

Pleas acknowledge our core in your publications when appropriate in the format that follows:  “University of Maryland School of Medicine Center for Innovative Biomedical Resources, Translation Laboratory Shared Services Core – Baltimore, Maryland.

Leadership

Rena Lapidus, Ph.D., Director

Location and Hours of Operation

Hours Location

Monday - Friday    

8:30 am - 5:00 pm       

655 West Baltimore Street

Baltimore, MD  21201

Links and Resources

University of Maryland School of Medicine - Translational Core Laboratory

Biotek Synergy H1 Multimode Plate Reader

xCELLigence RTCA DP

 

Contacts

Name Role Phone Email Location
Rena Lapidus, PhD
Core Director
 
410-328-8092
 
RLapidus@som.umaryland.edu
 
BRB 7-043
 
Brandon Carter-Cooper
Lab Manager
 
410-706-2171
 
BCooper@som.umaryland.edu
 
BRB 7-010C
 

Service list


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In Vitro (24)
In Vivo (17)
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